منابع مشابه
Drug dosing during continuous renal replacement therapy.
Continuous renal replacement therapy (CRRT) has given clinicians an important option in the care of critically ill patients. The slow and continuous dialysate and ultrafiltrate flow rates that are employed with CRRT can yield drug clearances similar to an analogous glomerular filtration rate of the native kidneys. Advantages such as superior volume control, excellent metabolic control, and hemo...
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The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency are presented in tabular form. Current medical literature was extensively surveyed to provide as much specific information as possible. When information is lacking, however, recommendations are based on pharmacokinetic variables in normal subjects. Nephrotoxicity, important adverse eff...
متن کاملChallenges in developing evidence-based drug dosing guidelines for adults and children receiving renal replacement therapy.
The challenges of appropriate drug dosing in patients with renal failure requiring renal replacement therapy (RRT) have been exacerbated by recent trends in both RRT technology and practices. Nearly all these changes have resulted in augmented drug clearance, making most existing RRT drug dosing recommendations obsolete. Many barriers exist to conducting research to update our knowledge of appr...
متن کاملDrug-induced encephalopathy secondary to non renal dosing of common medications in Two dialysis patients.
The U.S. end-stage renal disease (ESRD) population continues to increase. Adjustment of several drugs administered to dialysis patients is mandatory because of decreased--and sometimes totally absent--renal clearances. Gabapentin, a newer anticonvulsant increasingly used for several other clinical indications, is excreted in the urine unchanged. Its half-life of 5 - 9 hours is increased to up t...
متن کاملDrug Dosing and Estimated Renal Function - Any Step Forward from Effersoe?
Drug dosing in accordance with the renal function is a long-standing challenge to clinicians. For many years it has been evident that in many clinical situations there is no easy way to correctly dose any drug that is mainly cleared by the kidneys. Despite the development of many formulas for estimating the glomerular filtration rate, they all have serious shortcomings. Much effort has been put...
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ژورنال
عنوان ژورنال: Applied Clinical Informatics
سال: 2016
ISSN: 1869-0327
DOI: 10.4338/aci-2016-01-ra-0010